Version 5.4
Homo sapiens Protein: SPRR2A
Summary
InnateDB Protein IDBP-245224.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPRR2A
Protein Name small proline-rich protein 2A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376423
InnateDB Gene IDBG-409215 (SPRR2A)
Protein Structure
UniProt Annotation
Function Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008544 epidermis development
GO:0030216 keratinocyte differentiation
GO:0031424 keratinization
Cellular Component
GO:0001533 cornified envelope
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35326
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 6700
UniGene
RefSeq NP_005979
HUGO HGNC:11261
OMIM 182267
CCDS CCDS1034
HPRD 01649
IMGT
EMBL AK311939 AL356867 BC096108 BC096109 BC096110 BC096111 BC128049 CH471121 X53064
GenPept AAH96108 AAH96109 AAH96110 AAH96111 AAI28050 BAG34880 CAA37239 CAI19807 EAW53346 EAW53347

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca