InnateDB Protein
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IDBP-245286.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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S100A13
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Protein Name
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S100 calcium binding protein A13
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376399
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InnateDB Gene
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IDBG-102736 (S100A13)
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Protein Structure
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Function |
Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm. Secreted. Note=Secretion is mediated by exposure to stress and requires copper ions.
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Disease Associations |
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Tissue Specificity |
Expressed in heart and skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013787
S100/CaBP-9k-type, calcium binding, subdomain
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PFAM |
PF01023
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99584
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PhosphoSite |
PhosphoSite-Q99584
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TrEMBL |
D3DV53
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UniProt Splice Variant |
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Entrez Gene |
6284
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UniGene |
Hs.737210
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RefSeq |
NP_001019383
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HUGO |
HGNC:10490
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OMIM |
601989
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CCDS |
CCDS30874
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HPRD |
03586
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IMGT |
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EMBL |
AY987392
BC000632
BC068064
BC070291
BT006724
BX470102
CH471121
CR542149
X99920
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GenPept |
AAH00632
AAH68064
AAH70291
AAP35370
AAX89402
CAA68188
CAG46946
CAI14760
EAW53296
EAW53297
EAW53300
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