InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: B3GAT1

Summary

InnateDB Protein

IDBP-245376.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B3GAT1

Protein Name

beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376359

InnateDB Gene

IDBG-76619 (B3GAT1)

Protein Structure

UniProt Annotation

Function

Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Mainly expressed in the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006486	protein glycosylation
GO:0008152	metabolic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0044281	small molecule metabolic process