InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRB2

Summary

InnateDB Protein

IDBP-245406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRB2

Protein Name

growth factor receptor-bound protein 2

Synonyms

ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084; NCKAP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000376346

InnateDB Gene

IDBG-68262 (GRB2)

Protein Structure

UniProt Annotation

Function

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

Subcellular Localization

Nucleus {ECO:0000269PubMed:21179510}. Cytoplasm {ECO:0000269PubMed:21179510}. Endosome {ECO:0000269PubMed:21179510}. Golgi apparatus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 663 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.

Experimentally validated
Total	663 [view]
Protein-Protein	660 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	70 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005154	epidermal growth factor receptor binding
GO:0005168	neurotrophin TRKA receptor binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0043560	insulin receptor substrate binding
GO:0044822	poly(A) RNA binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007265	Ras protein signal transduction
GO:0007267	cell-cell signaling
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0016032	viral process
GO:0030168	platelet activation
GO:0031295	T cell costimulation
GO:0031623	receptor internalization
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042770	signal transduction in response to DNA damage
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050900	leukocyte migration
GO:0071479	cellular response to ionizing radiation
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0008180	COP9 signalosome
GO:0070062	extracellular vesicular exosome
GO:0070436	Grb2-EGFR complex