InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACAP1

Summary

InnateDB Protein

IDBP-24570.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACAP1

Protein Name

ArfGAP with coiled-coil, ankyrin repeat and PH domains 1

Synonyms

CENTB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000158762

InnateDB Gene

IDBG-24566 (ACAP1)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. {ECO:0000269PubMed:11062263, ECO:0000269PubMed:16256741, ECO:0000269PubMed:17398097, ECO:0000269PubMed:17664335, ECO:0000269PubMed:22645133}.

Subcellular Localization

Recycling endosome membrane {ECO:0000269PubMed:16256741}; Peripheral membrane protein {ECO:0000269PubMed:16256741}; Cytoplasmic side {ECO:0000269PubMed:16256741}.

Disease Associations

Tissue Specificity

Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas. {ECO:0000269PubMed:11062263}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding

Biological Process

GO:0015031	protein transport
GO:0032312	regulation of ARF GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0016020	membrane
GO:0055038	recycling endosome membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001164 Arf GTPase activating protein
IPR001849 Pleckstrin homology domain
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain

PFAM