InnateDB Protein
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IDBP-245858.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC16A3
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Protein Name
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solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
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Synonyms
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MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376152
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InnateDB Gene
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IDBG-73352 (SLC16A3)
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Protein Structure
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Function |
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Highly expressed in skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008028
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monocarboxylic acid transmembrane transporter activity
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GO:0015293
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symporter activity
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GO:0015355
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secondary active monocarboxylate transmembrane transporter activity
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GO:0044822
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poly(A) RNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004743
Monocarboxylate transporter
IPR011701
Major facilitator superfamily
IPR016196
Major facilitator superfamily domain, general substrate transporter
IPR020846
Major facilitator superfamily domain
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PFAM |
PF07690
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O15427
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PhosphoSite |
PhosphoSite-O15427
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TrEMBL |
J3QSC3
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UniProt Splice Variant |
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Entrez Gene |
9123
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UniGene |
Hs.641748
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RefSeq |
NP_001193879
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HUGO |
HGNC:10924
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OMIM |
603877
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CCDS |
CCDS11804
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HPRD |
04854
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IMGT |
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EMBL |
AC132872
AK127319
BC112267
BC112269
CH471099
U81800
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GenPept |
AAC52015
AAI12268
AAI12270
BAG54480
EAW89753
EAW89754
EAW89756
EAW89757
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