Version 5.4
Homo sapiens Protein: MPZL1
Summary
InnateDB Protein IDBP-246304.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPZL1
Protein Name myelin protein zero-like 1
Synonyms MPZL1b; PZR; PZR1b; PZRa; PZRb;
Species Homo sapiens
Ensembl Protein ENSP00000375968
InnateDB Gene IDBG-104564 (MPZL1)
Protein Structure
UniProt Annotation
Function Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. {ECO:0000269PubMed:11751924, ECO:0000269PubMed:12410637}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line. {ECO:0000269PubMed:12410637, ECO:0000269PubMed:12684038, ECO:0000269PubMed:9792637}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267 cell-cell signaling
Cellular Component
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95297
PhosphoSite PhosphoSite-O95297
TrEMBL
UniProt Splice Variant
Entrez Gene 9019
UniGene Hs.705572
RefSeq NP_001139663
HUGO HGNC:7226
OMIM 604376
CCDS CCDS53425
HPRD 05086
IMGT
EMBL AF087020 AF092424 AF092425 AF095726 AF095727 AF239756 AF478447 AF478448 AK297112 AL356532 AY359019 BC007881 CH471067 CR542160 Z99943
GenPept AAC72231 AAD55346 AAD55347 AAF00083 AAF00084 AAF63499 AAH07881 AAO14645 AAO14646 AAO14647 AAQ89378 BAH12501 CAC36033 CAG46957 CAI20143 CAI20144 CAQ52583 CAQ52584 CAQ52610 CAQ52611 EAW90800

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca