InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERCC2

Summary

InnateDB Protein

IDBP-246666.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERCC2

Protein Name

excision repair cross-complementing rodent repair deficiency, complementation group 2

Synonyms

COFS2; EM9; TFIIH; TTD; XPD;

Species

Homo sapiens

Ensembl Protein

ENSP00000375808

InnateDB Gene

IDBG-57385 (ERCC2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.

Experimentally validated
Total	43 [view]
Protein-Protein	42 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006200	ATP catabolic process
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR006554 Helicase-like, DEXD box c2 type
IPR006555 ATP-dependent helicase, C-terminal
IPR010614 DEAD2
IPR010643 Domain of unknown function DUF1227
IPR013020 DNA helicase (DNA repair), Rad3 type
IPR014013 Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF13307
PF06733
PF06777

PRINTS

PIRSF

SMART

SM00488
SM00491

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite