InnateDB Protein
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IDBP-24685.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MAZ
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Protein Name
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MYC-associated zinc finger protein (purine-binding transcription factor)
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Synonyms
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Pur-1; PUR1; SAF-1; SAF-2; SAF-3; ZF87; Zif87; ZNF801;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000313362
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InnateDB Gene
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IDBG-24683 (MAZ)
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Protein Structure
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Function |
May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins. {ECO:0000269PubMed:12270922}.
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Subcellular Localization |
Nucleus {ECO:0000305PubMed:10727212}. Note=In brains of Alzheimer disease patients, present in a plaque- like structures.
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Disease Associations |
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Tissue Specificity |
Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level). {ECO:0000269PubMed:10727212}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0006369
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termination of RNA polymerase II transcription
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Cellular Component |
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PDB ID |
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
P56270
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PhosphoSite |
PhosphoSite-P56270
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TrEMBL |
Q9UJ31
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UniProt Splice Variant |
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Entrez Gene |
4150
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UniGene |
Hs.736405
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RefSeq |
NP_002374
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HUGO |
HGNC:6914
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OMIM |
600999
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CCDS |
CCDS42143
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HPRD |
02999
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IMGT |
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EMBL |
AB017335
AC002301
AC009133
AF489858
CH471238
D85131
EF059746
FJ532357
M93339
M94046
U33819
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GenPept |
AAB04121
AAC08710
AAN03800
ABN80996
ACS26236
BAA12728
BAA33064
EAW79994
EAW79996
EAW79997
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