InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRMT1

Summary

InnateDB Protein

IDBP-246857.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRMT1

Protein Name

protein arginine methyltransferase 1

Synonyms

ANM1; HCP1; HRMT1L2; IR1B4;

Species

Homo sapiens

Ensembl Protein

ENSP00000375724

InnateDB Gene

IDBG-63299 (PRMT1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 206 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	206 [view]
Protein-Protein	201 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008170	N-methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0016740	transferase activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0042802	identical protein binding
GO:0044020	histone methyltransferase activity (H4-R3 specific)
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0007166	cell surface receptor signaling pathway
GO:0008152	metabolic process
GO:0016571	histone methylation
GO:0018216	peptidyl-arginine methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0031175	neuron projection development
GO:0043985	histone H4-R3 methylation
GO:0045087	innate immune response (InnateDB)
GO:0045653	negative regulation of megakaryocyte differentiation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR003402 tRNA transferase Trm5/Tyw2
IPR007848 Methyltransferase small domain
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR013216 Methyltransferase type 11
IPR025799 Protein arginine N-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF02475
PF05175
PF06325
PF08241
PF05185

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99873

PhosphoSite