Version 5.4
Homo sapiens Protein: KLK5
Summary
InnateDB Protein IDBP-246943.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK5
Protein Name kallikrein-related peptidase 5
Synonyms KLK-L2; KLKL2; SCTE;
Species Homo sapiens
Ensembl Protein ENSP00000375685
InnateDB Gene IDBG-65175 (KLK5)
Protein Structure
UniProt Annotation
Function May be involved in desquamation.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin. {ECO:0000269PubMed:19190773}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0008544 epidermis development
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0097209 epidermal lamellar body
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y337
PhosphoSite PhosphoSite-Q9Y337
TrEMBL Q8IU55
UniProt Splice Variant
Entrez Gene 25818
UniGene Hs.50915
RefSeq NP_001070959
HUGO HGNC:6366
OMIM 605643
CCDS CCDS12810
HPRD 05732
IMGT
EMBL AC011483 AF135028 AF168768 AF243527 AF435980 AF435981 AY279380 AY279381 AY359010 BC008036 BT006867 CH471135
GenPept AAD26429 AAF03101 AAG33358 AAH08036 AAN63606 AAN63607 AAP35513 AAP42275 AAP42276 AAQ89369 EAW71946 EAW71948 EAW71949 EAW71950 EAW71952

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca