Version 5.4
Homo sapiens Protein: KLK7
Summary
InnateDB Protein IDBP-246947.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK7
Protein Name kallikrein-related peptidase 7
Synonyms hK7; PRSS6; SCCE;
Species Homo sapiens
Ensembl Protein ENSP00000375683
InnateDB Gene IDBG-65268 (KLK7)
Protein Structure
UniProt Annotation
Function May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr--Gln-15' and insulin B chain at '6- Leu--Cys-7', '16-Tyr--Leu-17', '25-Phe--Tyr-26' and '26-Tyr-- Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. {ECO:0000269PubMed:23370777}.
Subcellular Localization Secreted {ECO:0000269PubMed:12738725}. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.
Disease Associations
Tissue Specificity Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). {ECO:0000269PubMed:10974542, ECO:0000269PubMed:12738725}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0008544 epidermis development
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005576 extracellular region
GO:0097209 epidermal lamellar body
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49862
PhosphoSite PhosphoSite-P49862
TrEMBL X2J289
UniProt Splice Variant
Entrez Gene 5650
UniGene Hs.151254
RefSeq NP_644806
HUGO HGNC:6368
OMIM 604438
CCDS CCDS12812
HPRD 05115
IMGT
EMBL AC011483 AF166330 AF243527 AF332583 AF411214 AF411215 AK289660 AK295313 AY601109 BC032005 CH471135 KF963189 L33404
GenPept AAC37551 AAD49718 AAG33360 AAH32005 AAK69624 AAN03662 AAN03663 AAU04540 AHN52223 BAF82349 BAG58291 EAW71959 EAW71960 EAW71961

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca