InnateDB Protein
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IDBP-247055.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MBOAT7
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Protein Name
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membrane bound O-acyltransferase domain containing 7
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000375634
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InnateDB Gene
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IDBG-68251 (MBOAT7)
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Protein Structure
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Function |
Acyltransferase which mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3- phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269PubMed:18094042, ECO:0000269PubMed:18772128}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Overexpressed in metastatic breast and bladder carcinomas relative to normal breast epithelium and urothelium. {ECO:0000269PubMed:18772128}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0016747
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transferase activity, transferring acyl groups other than amino-acyl groups
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004299
Membrane bound O-acyl transferase, MBOAT
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PFAM |
PF03062
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96N66
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PhosphoSite |
PhosphoSite-Q96N66
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TrEMBL |
C9J4E9
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UniProt Splice Variant |
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Entrez Gene |
79143
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UniGene |
Hs.467279
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RefSeq |
NP_001139554
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HUGO |
HGNC:15505
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OMIM |
606048
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CCDS |
CCDS54316
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HPRD |
06925
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IMGT |
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EMBL |
AC012314
AK055908
AK298689
BC002512
BC003164
BC006309
BC015857
CH471135
CU151838
CU457734
EU016381
S82470
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GenPept |
AAB37433
AAH02512
AAH03164
AAH06309
AAH15857
ABV66273
BAB71043
BAG60849
CAP19119
CAP19120
CAQ09590
CAQ09591
EAW72199
EAW72202
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