InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apc

Summary

InnateDB Protein

IDBP-248875.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apc

Protein Name

adenomatosis polyposis coli

Synonyms

AI047805; AU020952; AW124434; CC1; mAPC; Min;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111447

InnateDB Gene

IDBG-134573 (Apc)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 133 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	35 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	133 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008017	microtubule binding
GO:0051010	microtubule plus-end binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0001822	kidney development
GO:0001942	hair follicle development
GO:0006974	cellular response to DNA damage stimulus
GO:0007026	negative regulation of microtubule depolymerization
GO:0007050	cell cycle arrest
GO:0007091	metaphase/anaphase transition of mitotic cell cycle
GO:0007389	pattern specification process
GO:0007409	axonogenesis
GO:0008285	negative regulation of cell proliferation
GO:0009798	axis specification
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0009954	proximal/distal pattern formation
GO:0016055	Wnt signaling pathway
GO:0016477	cell migration
GO:0019827	stem cell maintenance
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030334	regulation of cell migration
GO:0030335	positive regulation of cell migration
GO:0030856	regulation of epithelial cell differentiation
GO:0030858	positive regulation of epithelial cell differentiation
GO:0031116	positive regulation of microtubule polymerization
GO:0031122	cytoplasmic microtubule organization
GO:0033077	T cell differentiation in thymus
GO:0035019	somatic stem cell maintenance
GO:0042483	negative regulation of odontogenesis
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043409	negative regulation of MAPK cascade
GO:0043588	skin development
GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0045595	regulation of cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0045667	regulation of osteoblast differentiation
GO:0045670	regulation of osteoclast differentiation
GO:0045732	positive regulation of protein catabolic process
GO:0045785	positive regulation of cell adhesion
GO:0046716	muscle cell cellular homeostasis
GO:0048538	thymus development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051171	regulation of nitrogen compound metabolic process
GO:0051276	chromosome organization
GO:0051726	regulation of cell cycle
GO:0051781	positive regulation of cell division
GO:0051988	regulation of attachment of spindle microtubules to kinetochore
GO:0060041	retina development in camera-type eye
GO:0060070	canonical Wnt signaling pathway
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005881	cytoplasmic microtubule
GO:0030424	axon
GO:0030426	growth cone
GO:0031253	cell projection membrane
GO:0035371	microtubule plus-end
GO:0042995	cell projection
GO:0044295	axonal growth cone

Protein Structure and Domains

PDB ID

MGI:88039

InterPro

IPR000225 Armadillo
IPR009223 Adenomatous polyposis coli protein, cysteine-rich repeat
IPR009224 SAMP
IPR009232 EB-1 binding
IPR009234 Adenomatous polyposis coli protein basic domain
IPR009240 Adenomatous polyposis coli protein, 15 residue repeat
IPR016024 Armadillo-type fold
IPR026831 Adenomatous polyposis coli domain

PFAM