InnateDB Protein
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IDBP-249727.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Atp6v0c
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Protein Name
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ATPase, H+ transporting, lysosomal V0 subunit C
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Synonyms
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Atp6c; Atp6c2; Atp6l; Atpl; Atpl-rs1; PL16; VATL; Vma3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000111059
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InnateDB Gene
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IDBG-145384 (Atp6v0c)
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Protein Structure
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Function |
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
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Subcellular Localization |
Vacuole membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0008553
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hydrogen-exporting ATPase activity, phosphorylative mechanism
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GO:0015078
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hydrogen ion transmembrane transporter activity
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GO:0031625
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ubiquitin protein ligase binding
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Biological Process |
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Cellular Component |
GO:0005765
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lysosomal membrane
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GO:0016021
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integral component of membrane
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GO:0016471
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vacuolar proton-transporting V-type ATPase complex
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GO:0033177
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proton-transporting two-sector ATPase complex, proton-transporting domain
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GO:0033179
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proton-transporting V-type ATPase, V0 domain
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PDB ID |
MGI:88116
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InterPro |
IPR000245
V-ATPase proteolipid subunit
IPR002379
V-ATPase proteolipid subunit C-like domain
IPR011555
V-ATPase proteolipid subunit C, eukaryotic
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PFAM |
PF00137
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PRINTS |
PR00122
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P63082
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PhosphoSite |
PhosphoSite-
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TrEMBL |
E9Q9C5
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UniProt Splice Variant |
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Entrez Gene |
11984
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UniGene |
Mm.449294
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RefSeq |
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MGI ID |
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MGI Symbol |
Atp6v0c
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OMIM |
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CCDS |
CCDS28476
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HPRD |
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IMGT |
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EMBL |
AB059662
AF356008
AK002570
AK002871
AK170346
BC083129
BC099475
BC132267
BC132611
CH466533
CH466606
CT010502
M64298
U13842
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GenPept |
AAA39775
AAC52413
AAH83129
AAH99475
AAI32268
AAI32612
AAL02098
BAB22195
BAB22419
BAB64538
BAE41735
EDL13651
EDL22293
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