Version 5.4
Mus musculus Protein: Enox2
Summary
InnateDB Protein IDBP-250743.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Enox2
Protein Name ecto-NOX disulfide-thiol exchanger 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000110568
InnateDB Gene IDBG-144224 (Enox2)
Protein Structure
UniProt Annotation
Function May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock (By similarity). {ECO:0000250UniProtKB:Q16206}.
Subcellular Localization Cell membrane {ECO:0000250}. Secreted, extracellular space {ECO:0000250}. Note=Extracellular and plasma membrane-associated. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0015035 protein disulfide oxidoreductase activity
Biological Process
GO:0007624 ultradian rhythm
GO:0040008 regulation of growth
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID MGI:2384799
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R0Z2
PhosphoSite PhosphoSite-Q8R0Z2
TrEMBL
UniProt Splice Variant
Entrez Gene 209224
UniGene Mm.398131
RefSeq XP_006541530
MGI ID
MGI Symbol Enox2
OMIM
CCDS CCDS30115
HPRD
IMGT
EMBL AK034058 AK041822 BC025915 BC026450 BX294194
GenPept AAH25915 AAH26450 BAC28565 BAC31077 CAM21582

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca