Version 5.4
Mus musculus Protein: Gpc3
Summary
InnateDB Protein IDBP-250882.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Gpc3
Protein Name glypican 3
Synonyms OCI-5;
Species Mus musculus
Ensembl Protein ENSMUSP00000110507
InnateDB Gene IDBG-145213 (Gpc3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0060422 peptidyl-dipeptidase inhibitor activity
Biological Process
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0008285 negative regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0009948 anterior/posterior axis specification
GO:0010171 body morphogenesis
GO:0010466 negative regulation of peptidase activity
GO:0030282 bone mineralization
GO:0030316 osteoclast differentiation
GO:0030324 lung development
GO:0030513 positive regulation of BMP signaling pathway
GO:0035116 embryonic hindlimb morphogenesis
GO:0040008 regulation of growth
GO:0045732 positive regulation of protein catabolic process
GO:0045807 positive regulation of endocytosis
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045926 negative regulation of growth
GO:0046326 positive regulation of glucose import
GO:0050680 negative regulation of epithelial cell proliferation
GO:0060976 coronary vasculature development
GO:0072111 cell proliferation involved in kidney development
GO:0072180 mesonephric duct morphogenesis
GO:0072203 cell proliferation involved in metanephros development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000096 positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0046658 anchored component of plasma membrane
Protein Structure and Domains
PDB ID MGI:104903
InterPro IPR001863 Glypican
PFAM PF01153
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B1ATR5
UniProt Splice Variant
Entrez Gene 14734
UniGene Mm.470634
RefSeq
MGI ID
MGI Symbol Gpc3
OMIM
CCDS
HPRD
IMGT
EMBL AL663064 AL671426 AL672019
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca