InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gls

Summary

InnateDB Protein

IDBP-251606.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gls

Protein Name

glutaminase

Synonyms

6330442B14; AI314027; B230365M23Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110158

InnateDB Gene

IDBG-153335 (Gls)

Protein Structure

UniProt Annotation

Function

Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. {ECO:0000269PubMed:16641247, ECO:0000269PubMed:22228304, ECO:0000269PubMed:22373647}.

Subcellular Localization

Isoform 1: Cytoplasm, cytosol {ECO:0000250}.Isoform 2: Mitochondrion.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004359	glutaminase activity
GO:0005515	protein binding

Biological Process

GO:0001967	suckling behavior
GO:0002087	regulation of respiratory gaseous exchange by neurological system process
GO:0006537	glutamate biosynthetic process
GO:0006541	glutamine metabolic process
GO:0006543	glutamine catabolic process
GO:0007268	synaptic transmission
GO:0051289	protein homotetramerization