InnateDB Protein
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IDBP-251891.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Entpd8
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Protein Name
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ectonucleoside triphosphate diphosphohydrolase 8
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000110017
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InnateDB Gene
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IDBG-143977 (Entpd8)
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Protein Structure
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Function |
Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP. {ECO:0000269PubMed:15122917}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in liver, jejunum and kidney. {ECO:0000269PubMed:15122917}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
GO:0009124
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nucleoside monophosphate biosynthetic process
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GO:0009133
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nucleoside diphosphate biosynthetic process
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Cellular Component |
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PDB ID |
MGI:1919340
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InterPro |
IPR000407
Nucleoside phosphatase GDA1/CD39
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PFAM |
PF01150
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8K0L2
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PhosphoSite |
PhosphoSite-Q8K0L2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
72090
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UniGene |
Mm.33403
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RefSeq |
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MGI ID |
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MGI Symbol |
Entpd8
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AL732585
AY364442
BC031143
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GenPept |
AAH31143
AAQ84519
CAM17997
CAM17998
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