Mus musculus Protein: Samsn1 | |||||||||
---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||
InnateDB Protein | IDBP-252184.6 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | Samsn1 | ||||||||
Protein Name | SAM domain, SH3 domain and nuclear localization signals, 1 | ||||||||
Synonyms | 4930571B16Rik; 930571B16Rik; Hacs1; SLy2; | ||||||||
Species | Mus musculus | ||||||||
Ensembl Protein | ENSMUSP00000109877 | ||||||||
InnateDB Gene | IDBG-171448 (Samsn1) | ||||||||
Protein Structure | |||||||||
UniProt Annotation | |||||||||
Function | Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation. {ECO:0000269PubMed:15381729, ECO:0000269PubMed:19923443, ECO:0000269PubMed:20478393, ECO:0000269PubMed:21296879}. | ||||||||
Subcellular Localization | Nucleus. Cytoplasm. Cell projection, ruffle. Note=Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles. | ||||||||
Disease Associations | |||||||||
Tissue Specificity | Detected in spleen and lymph node (at protein level). {ECO:0000269PubMed:15381729}. | ||||||||
Comments | |||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
|
||||||||
Gene Ontology | |||||||||
Molecular Function |
|
||||||||
Biological Process |
|
||||||||
Cellular Component |
|
||||||||
Protein Structure and Domains | |||||||||
PDB ID | MGI:1914992 | ||||||||
InterPro |
IPR001452
SH3 domain IPR001660 Sterile alpha motif domain IPR011510 Sterile alpha motif, type 2 IPR011511 Variant SH3 domain IPR013761 Sterile alpha motif/pointed domain IPR021090 SAM/SH3 domain-containing IPR021129 Sterile alpha motif, type 1 |
||||||||
PFAM |
PF00018
PF14604 PF07647 PF07653 PF12485 PF00536 |
||||||||
PRINTS |
PR00452
|
||||||||
PIRSF | |||||||||
SMART |
SM00326
SM00454 |
||||||||
TIGRFAMs | |||||||||
Post-translational Modifications | |||||||||
Modification | |||||||||
Cross-References | |||||||||
SwissProt | P57725 | ||||||||
PhosphoSite | PhosphoSite-P57725 | ||||||||
TrEMBL | |||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 67742 | ||||||||
UniGene | Mm.473571 | ||||||||
RefSeq | NP_075869 | ||||||||
MGI ID | 1V38 | ||||||||
MGI Symbol | Samsn1 | ||||||||
OMIM | |||||||||
CCDS | CCDS37378 | ||||||||
HPRD | |||||||||
IMGT | |||||||||
EMBL | AF222928 AK053946 BC052906 BC064778 DQ333189 | ||||||||
GenPept | AAG23356 AAH52906 AAH64778 ABC59720 BAC35601 | ||||||||