InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCNB1

Summary

InnateDB Protein

IDBP-25266.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNB1

Protein Name

cyclin B1

Synonyms

CCNB;

Species

Homo sapiens

Ensembl Protein

ENSP00000256442

InnateDB Gene

IDBG-25262 (CCNB1)

Protein Structure

UniProt Annotation

Function

Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269PubMed:17495531, ECO:0000269PubMed:17495533}.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 138 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	138 [view]
Protein-Protein	126 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005113	patched binding
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0019901	protein kinase binding
GO:0035173	histone kinase activity

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001556	oocyte maturation
GO:0001701	in utero embryonic development
GO:0001933	negative regulation of protein phosphorylation
GO:0006461	protein complex assembly
GO:0006468	protein phosphorylation
GO:0007077	mitotic nuclear envelope disassembly
GO:0007080	mitotic metaphase plate congression
GO:0007283	spermatogenesis
GO:0009612	response to mechanical stimulus
GO:0009636	response to toxic substance
GO:0010629	negative regulation of gene expression
GO:0016572	histone phosphorylation
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031442	positive regulation of mRNA 3'-end processing
GO:0033129	positive regulation of histone phosphorylation
GO:0042246	tissue regeneration
GO:0042493	response to drug
GO:0043148	mitotic spindle stabilization
GO:0045931	positive regulation of mitotic cell cycle
GO:0046680	response to DDT
GO:0048565	digestive tract development
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051726	regulation of cell cycle
GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore
GO:0055015	ventricular cardiac muscle cell development
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060623	regulation of chromosome condensation
GO:0071174	mitotic spindle checkpoint
GO:0071283	cellular response to iron(III) ion
GO:0071398	cellular response to fatty acid
GO:0071407	cellular response to organic cyclic compound
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0000922	spindle pole
GO:0000942	condensed nuclear chromosome outer kinetochore
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane