InnateDB Protein
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IDBP-253077.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Arpc2
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Protein Name
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actin related protein 2/3 complex, subunit 2
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Synonyms
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2210023N03Rik; 34kDa; p34-Arc;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000109451
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InnateDB Gene
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IDBG-166451 (Arpc2)
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Protein Structure
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Function |
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000269PubMed:24153177}.
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Disease Associations |
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Tissue Specificity |
Expressed in hippocampal neurons (at protein level). {ECO:0000269PubMed:24153177}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
27 [view]
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Molecular Function |
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Biological Process |
GO:0030833
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regulation of actin filament polymerization
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GO:0030838
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positive regulation of actin filament polymerization
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GO:1900026
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positive regulation of substrate adhesion-dependent cell spreading
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Cellular Component |
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PDB ID |
MGI:1923959
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InterPro |
IPR007188
ARP2/3 complex, 34kDa subunit (p34-Arc)
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PFAM |
PF04045
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CVB6
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PhosphoSite |
PhosphoSite-Q9CVB6
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TrEMBL |
Q4FZG5
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UniProt Splice Variant |
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Entrez Gene |
76709
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UniGene |
Mm.337038
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RefSeq |
XP_006496380
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MGI ID |
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MGI Symbol |
Arpc2
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OMIM |
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CCDS |
CCDS35612
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HPRD |
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IMGT |
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EMBL |
AK008777
AK151513
AK152356
BC099504
BC115750
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GenPept |
AAH99504
AAI15751
BAB25889
BAE30463
BAE31148
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