Version 5.4
| Mus musculus Protein: Plcd4 | |||||||||||||||
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| Summary | |||||||||||||||
| InnateDB Protein | IDBP-253211.6 | ||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
| Gene Symbol | Plcd4 | ||||||||||||||
| Protein Name | phospholipase C, delta 4 | ||||||||||||||
| Synonyms | 4921507K24Rik; | ||||||||||||||
| Species | Mus musculus | ||||||||||||||
| Ensembl Protein | ENSMUSP00000109379 | ||||||||||||||
| InnateDB Gene | IDBG-167412 (Plcd4) | ||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||
| Function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. {ECO:0000269PubMed:11340203, ECO:0000269PubMed:12695499, ECO:0000269PubMed:16998201}. | ||||||||||||||
| Subcellular Localization | Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum. {ECO:0000250}. | ||||||||||||||
| Disease Associations | |||||||||||||||
| Tissue Specificity | |||||||||||||||
| Comments | |||||||||||||||
| Interactions | |||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||
| PDB ID | MGI:107469 | ||||||||||||||
| InterPro |
IPR000008
C2 domain IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain IPR001192 Phosphoinositide phospholipase C family IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain IPR001849 Pleckstrin homology domain IPR002048 EF-hand domain IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
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| PFAM |
PF00168
PF00388 PF00387 PF00169 PF00036 PF13202 PF13405 PF09279 |
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| PRINTS |
PR00360
PR00390 |
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| PIRSF | |||||||||||||||
| SMART |
SM00239
SM00148 SM00149 SM00233 SM00054 |
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| TIGRFAMs | |||||||||||||||
| Post-translational Modifications | |||||||||||||||
| Modification | |||||||||||||||
| Cross-References | |||||||||||||||
| SwissProt | Q8K3R3 | ||||||||||||||
| PhosphoSite | PhosphoSite-Q8K3R3 | ||||||||||||||
| TrEMBL | |||||||||||||||
| UniProt Splice Variant | |||||||||||||||
| Entrez Gene | 18802 | ||||||||||||||
| UniGene | Mm.401433 | ||||||||||||||
| RefSeq | |||||||||||||||
| MGI ID | |||||||||||||||
| MGI Symbol | Plcd4 | ||||||||||||||
| OMIM | |||||||||||||||
| CCDS | |||||||||||||||
| HPRD | |||||||||||||||
| IMGT | |||||||||||||||
| EMBL | AK016945 AK039149 AK140231 AY033991 BC066156 | ||||||||||||||
| GenPept | AAH66156 AAK61537 BAB30513 BAC30256 BAE24292 | ||||||||||||||