Homo sapiens Protein: RNASE8
Summary
InnateDB Protein IDBP-2540.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNASE8
Protein Name ribonuclease, RNase A family, 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000311398
InnateDB Gene IDBG-2538 (RNASE8)
Protein Structure
UniProt Annotation
Function Has a low ribonuclease activity.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed prominently in the placenta and is not detected in any other tissues examined.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004522 pancreatic ribonuclease activity
Biological Process
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR001427 Pancreatic ribonuclease
IPR023412 Ribonuclease A-domain
PFAM PF00074
PRINTS PR00794
PIRSF
SMART SM00092
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDE3
PhosphoSite PhosphoSite-Q8TDE3
TrEMBL H2FJY7
UniProt Splice Variant
Entrez Gene 122665
UniGene
RefSeq NP_612204
HUGO HGNC:19277
OMIM 612485
CCDS CCDS9567
HPRD 17982
IMGT
EMBL AF473854 BC137537 BC137538 CH471078 HG328840 JQ361125 JQ361127
GenPept AAI37538 AAI37539 AAL89644 AEX57299 AEX57301 CDG31916 EAW66417