InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFSF13

Summary

InnateDB Protein

IDBP-25400.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFSF13

Protein Name

tumor necrosis factor (ligand) superfamily, member 13

Synonyms

APRIL; CD256; TALL-2; TALL2; TRDL-1; ZTNF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000314455

InnateDB Gene

IDBG-25388 (TNFSF13)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. {ECO:0000269PubMed:10973284}.

Subcellular Localization

Secreted {ECO:0000269PubMed:11571266}.

Disease Associations

Tissue Specificity

Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0048298	positive regulation of isotype switching to IgA isotypes