InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxp1

Summary

InnateDB Protein

IDBP-254106.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxp1

Protein Name

forkhead box P1

Synonyms

3110052D19Rik; 4932443N09Rik; AI461938; AW494214;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108955

InnateDB Gene

IDBG-172640 (Foxp1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. {ECO:0000269PubMed:14701752, ECO:0000269PubMed:16819554}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Highest expression in the lung, brain, and spleen. Lower expression in heart, skeletal muscle, kidney, small intestine (isoform 3 not present) and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	12 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008301	DNA binding, bending
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002329	pre-B cell differentiation
GO:0002639	positive regulation of immunoglobulin production
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0007507	heart development
GO:0007519	skeletal muscle tissue development
GO:0008045	motor neuron axon guidance
GO:0021517	ventral spinal cord development
GO:0030324	lung development
GO:0033152	immunoglobulin V(D)J recombination
GO:0045214	sarcomere organization
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048745	smooth muscle tissue development
GO:0050679	positive regulation of epithelial cell proliferation
GO:0055007	cardiac muscle cell differentiation
GO:0060043	regulation of cardiac muscle cell proliferation
GO:0061140	lung secretory cell differentiation
GO:0072358	cardiovascular system development
GO:1901249	regulation of lung goblet cell differentiation
GO:1901250	negative regulation of lung goblet cell differentiation
GO:2000727	positive regulation of cardiac muscle cell differentiation