InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif4e2

Summary

InnateDB Protein

IDBP-254309.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif4e2

Protein Name

eukaryotic translation initiation factor 4E member 2

Synonyms

2700069E09Rik; AI036339; AV129531; D0H0S6743E; Eif4el3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108859

InnateDB Gene

IDBG-177898 (Eif4e2)

Protein Structure

UniProt Annotation

Function

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. {ECO:0000269PubMed:15153109}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed with highest levels in testis, kidney and liver. {ECO:0000269PubMed:15153109}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0044822	poly(A) RNA binding