InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acvr1

Summary

InnateDB Protein

IDBP-255667.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acvr1

Protein Name

activin A receptor, type 1

Synonyms

ActR-I; ActRIA; Acvr; Acvrlk2; Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108220

InnateDB Gene

IDBG-172102 (Acvr1)

Protein Structure

UniProt Annotation

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved in left-right pattern formation during embryogenesis. {ECO:0000269PubMed:15531373}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005025	transforming growth factor beta receptor activity, type I
GO:0005524	ATP binding
GO:0016361	activin receptor activity, type I
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0042803	protein homodimerization activity
GO:0046332	SMAD binding
GO:0046872	metal ion binding
GO:0048185	activin binding
GO:0050431	transforming growth factor beta binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001569	patterning of blood vessels
GO:0001655	urogenital system development
GO:0001701	in utero embryonic development
GO:0001702	gastrulation with mouth forming second
GO:0001707	mesoderm formation
GO:0001755	neural crest cell migration
GO:0002526	acute inflammatory response
GO:0003143	embryonic heart tube morphogenesis
GO:0003183	mitral valve morphogenesis
GO:0003289	atrial septum primum morphogenesis
GO:0006468	protein phosphorylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007281	germ cell development
GO:0007368	determination of left/right symmetry
GO:0007369	gastrulation
GO:0007498	mesoderm development
GO:0007507	heart development
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0032924	activin receptor signaling pathway
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0045669	positive regulation of osteoblast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048641	regulation of skeletal muscle tissue development
GO:0051145	smooth muscle cell differentiation
GO:0060037	pharyngeal system development
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0060923	cardiac muscle cell fate commitment
GO:0061445	endocardial cushion cell fate commitment
GO:0071385	cellular response to glucocorticoid stimulus
GO:2000017	positive regulation of determination of dorsal identity
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0045177	apical part of cell
GO:0048179	activin receptor complex

Protein Structure and Domains

PDB ID

MGI:87911

InterPro

IPR000333 Ser/Thr protein kinase, TGFB receptor
IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003605 TGF beta receptor, GS motif
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF01064
PF00069
PF07714
PF08515

PRINTS

PR00653
PR00109

PIRSF

SMART

SM00220
SM00467
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt