Version 5.4
Mus musculus Protein: Alkbh2
Summary
InnateDB Protein IDBP-256350.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Alkbh2
Protein Name alkB, alkylation repair homolog 2 (E. coli)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000107898
InnateDB Gene IDBG-192205 (Alkbh2)
Protein Structure
UniProt Annotation
Function Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1- ethenoadenine. Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. {ECO:0000269PubMed:16174769, ECO:0000269PubMed:16642038, ECO:0000269PubMed:18519673}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16642038, ECO:0000269PubMed:18519673}.
Disease Associations
Tissue Specificity Detected in liver, testis and kidney (at protein level). Detected in heart and testis. {ECO:0000269PubMed:16174769, ECO:0000269PubMed:16642038, ECO:0000269PubMed:18519673}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008198 ferrous iron binding
GO:0016491 oxidoreductase activity
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0043734 DNA-N1-methyladenine dioxygenase activity
GO:0051747 cytosine C-5 DNA demethylase activity
Biological Process
GO:0006307 DNA dealkylation involved in DNA repair
GO:0035511 oxidative DNA demethylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2141032
InterPro IPR005123 Oxoglutarate/iron-dependent dioxygenase
PFAM PF03171
PF13640
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P6J4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 231642
UniGene Mm.332593
RefSeq XP_006530352
MGI ID
MGI Symbol Alkbh2
OMIM
CCDS CCDS19559
HPRD
IMGT
EMBL AK079195 BC062188
GenPept AAH62188 BAC37576

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca