InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Entpd1

Summary

InnateDB Protein

IDBP-256465.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Entpd1

Protein Name

ectonucleoside triphosphate diphosphohydrolase 1

Synonyms

2610206B08Rik; AA408691; Cd39; NTPDase-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107850

InnateDB Gene

IDBG-165147 (Entpd1)

Protein Structure

UniProt Annotation

Function

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0017110	nucleoside-diphosphatase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0009181	purine ribonucleoside diphosphate catabolic process
GO:0030168	platelet activation