Version 5.4
Mus musculus Protein: Erlin1
Summary
InnateDB Protein IDBP-256883.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Erlin1
Protein Name ER lipid raft associated 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000107659
InnateDB Gene IDBG-169008 (Erlin1)
Protein Structure
UniProt Annotation
Function Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:2387613
InterPro IPR001107 Band 7 protein
PFAM PF01145
PRINTS
PIRSF
SMART SM00244
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91X78
PhosphoSite PhosphoSite-Q91X78
TrEMBL E9PVM2
UniProt Splice Variant
Entrez Gene 226144
UniGene Mm.490042
RefSeq NP_001157832
MGI ID
MGI Symbol Erlin1
OMIM
CCDS CCDS29842
HPRD
IMGT
EMBL AC124693 AK133557 AK145990 BC011220 BC023849
GenPept AAH11220 AAH23849 BAE21724 BAE26812

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca