InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tctn1

Summary

InnateDB Protein

IDBP-257492.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tctn1

Protein Name

tectonic family member 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107367

InnateDB Gene

IDBG-198038 (Tctn1)

Protein Structure

UniProt Annotation

Function

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23. {ECO:0000269PubMed:16357211, ECO:0000269PubMed:21725307, ECO:0000269PubMed:22179047}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium basal body. Secreted. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Despite the presence of a signal sequence, the full length protein might not be secreted (PubMed:16357211). {ECO:0000269PubMed:16357211}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001841	neural tube formation
GO:0008589	regulation of smoothened signaling pathway
GO:0021523	somatic motor neuron differentiation
GO:0021537	telencephalon development
GO:0021904	dorsal/ventral neural tube patterning
GO:0021956	central nervous system interneuron axonogenesis
GO:0060271	cilium morphogenesis