InnateDB Protein
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IDBP-25776.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CXCL13
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Protein Name
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chemokine (C-X-C motif) ligand 13
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Synonyms
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ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; SCYB13;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000286758
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InnateDB Gene
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IDBG-25774 (CXCL13)
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Protein Structure
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Function |
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0002467
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germinal center formation
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GO:0002518
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lymphocyte chemotaxis across high endothelial venule
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GO:0002544
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chronic inflammatory response
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GO:0002920
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regulation of humoral immune response
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GO:0006955
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immune response
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GO:0007166
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cell surface receptor signaling pathway
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GO:0007204
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positive regulation of cytosolic calcium ion concentration
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GO:0007267
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cell-cell signaling
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GO:0010820
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positive regulation of T cell chemotaxis
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GO:0032861
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activation of Rap GTPase activity
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GO:0033625
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positive regulation of integrin activation
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GO:0033634
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positive regulation of cell-cell adhesion mediated by integrin
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GO:0035754
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B cell chemotaxis
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GO:0035768
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endothelial cell chemotaxis to fibroblast growth factor
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GO:0035769
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B cell chemotaxis across high endothelial venule
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GO:0042742
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defense response to bacterium
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GO:0045765
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regulation of angiogenesis
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GO:0048535
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lymph node development
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GO:2000545
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negative regulation of endothelial cell chemotaxis to fibroblast growth factor
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Cellular Component |
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PDB ID |
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InterPro |
IPR001089
CXC chemokine
IPR001811
Chemokine interleukin-8-like domain
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PFAM |
PF00048
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PRINTS |
PR00437
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PIRSF |
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SMART |
SM00199
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TIGRFAMs |
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Modification |
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SwissProt |
O43927
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PhosphoSite |
PhosphoSite-O43927
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TrEMBL |
Q53X90
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UniProt Splice Variant |
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Entrez Gene |
10563
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UniGene |
Hs.100431
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RefSeq |
NP_006410
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HUGO |
HGNC:10639
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OMIM |
605149
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CCDS |
CCDS3582
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HPRD |
05513
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IMGT |
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EMBL |
AC093758
AF029894
AF044197
AJ002211
BC012589
CH471057
CR407624
EF064743
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GenPept |
AAC14402
AAC17980
AAH12589
AAY40955
ABK41926
CAA05250
CAG28552
EAX05816
EAX05817
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