Mus musculus Protein: Ran | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-258336.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Ran | ||||||||||||||||||||||
Protein Name | RAN, member RAS oncogene family | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000106975 | ||||||||||||||||||||||
InnateDB Gene | IDBG-201755 (Ran) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000269PubMed:18347012}. Cytoplasm {ECO:0000269PubMed:18347012}. Melanosome {ECO:0000250}. Note=Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed in a variety of tissues, including testis. {ECO:0000269PubMed:7849398}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:1333112 | ||||||||||||||||||||||
InterPro |
IPR001806
Small GTPase superfamily IPR002041 Ran GTPase IPR003578 Small GTPase superfamily, Rho type IPR003579 Small GTPase superfamily, Rab type IPR005225 Small GTP-binding protein domain IPR006689 Small GTPase superfamily, ARF/SAR type IPR013684 Mitochondrial Rho-like IPR020849 Small GTPase superfamily, Ras type IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00071
PF00025 PF08477 |
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PRINTS |
PR00449
PR00627 PR00328 |
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PIRSF | |||||||||||||||||||||||
SMART |
SM00176
SM00174 SM00175 SM00173 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P62827 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P62827 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 19384 | ||||||||||||||||||||||
UniGene | Mm.468040 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Ran | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS19693 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF159256 AK010569 AK010672 AK012268 AK012844 AK075900 AK087974 AK151341 AK151937 AK153197 AK153411 AK160647 AK167040 AK168183 BC014829 BC083356 L32751 M79316 S83456 | ||||||||||||||||||||||
GenPept | AAA64247 AAB50841 AAD45343 AAH14829 AAH83356 AAK14838 BAB27034 BAB27105 BAC36040 BAC40068 BAE30319 BAE30813 BAE31797 BAE31971 BAE35939 BAE39208 BAE40143 | ||||||||||||||||||||||