InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ap1s1

Summary

InnateDB Protein

IDBP-258882.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ap1s1

Protein Name

adaptor protein complex AP-1, sigma 1

Synonyms

AP19;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106709

InnateDB Gene

IDBG-204780 (Ap1s1)

Protein Structure

UniProt Annotation

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Subcellular Localization

Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Disease Associations

Tissue Specificity

Detected in brain and embryonic stem cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0009615	response to virus
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport