InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd209b

Summary

InnateDB Protein

IDBP-259003.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd209b

Protein Name

CD209b antigen

Synonyms

1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7; SIGNR1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106643

InnateDB Gene

IDBG-130726 (Cd209b)

Protein Structure

UniProt Annotation

Function

Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in skin, spleen and lung, probably in a subset of dendritic cells. Detected in spleen extrafollicular paracortical areas including the red pulp and marginal zones, and at lower levels, in the follicular area. Detected in skin suprabasal areas adjacent to the epidermis and in epidermal cell layer. {ECO:0000269PubMed:12137941}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001872	(1->3)-beta-D-glucan binding
GO:0005537	mannose binding
GO:0030247	polysaccharide binding
GO:0046872	metal ion binding

Biological Process

GO:0001879	detection of yeast
GO:0006897	endocytosis
GO:0006910	phagocytosis, recognition
GO:0016045	detection of bacterium
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0050766	positive regulation of phagocytosis