Version 5.4
Homo sapiens Protein: CD68
Summary
InnateDB Protein IDBP-25925.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD68
Protein Name CD68 molecule
Synonyms GP110; LAMP4; SCARD1;
Species Homo sapiens
Ensembl Protein ENSP00000250092
InnateDB Gene IDBG-25923 (CD68)
Protein Structure
UniProt Annotation
Function Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Subcellular Localization Isoform Short: Cell membrane; Single-pass type I membrane protein.Isoform Long: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. {ECO:0000269PubMed:18405323}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 3 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002000 Lysosome-associated membrane glycoprotein
PFAM PF01299
PRINTS PR00336
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P34810
PhosphoSite PhosphoSite-P34810
TrEMBL B4DNT7
UniProt Splice Variant
Entrez Gene 968
UniGene Hs.647419
RefSeq NP_001242
HUGO HGNC:1693
OMIM 153634
CCDS CCDS11114
HPRD 01093
IMGT
EMBL AC016876 AF060540 AK222492 AK222514 AK290238 AK298055 AK301223 BC015557 BT009923 CH471108 S57235
GenPept AAB25811 AAC70006 AAH15557 AAP88925 BAD96212 BAD96234 BAF82927 BAG60349 BAG62796 EAW90165

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca