InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sun1

Summary

InnateDB Protein

IDBP-259310.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sun1

Protein Name

Sad1 and UNC84 domain containing 1

Synonyms

4632417G13Rik; 5730434D03Rik; mKIAA0810; Unc84a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106507

InnateDB Gene

IDBG-206439 (Sun1)

Protein Structure

UniProt Annotation

Function

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non- coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). Required for efficient localization of SYNE4 in the nuclear envelope. {ECO:0000269PubMed:16380439, ECO:0000269PubMed:17543860, ECO:0000269PubMed:19211677, ECO:0000269PubMed:19509342, ECO:0000269PubMed:19874786, ECO:0000269PubMed:23348741}.

Subcellular Localization

Nucleus inner membrane {ECO:0000269PubMed:11593002, ECO:0000269PubMed:12036294, ECO:0000269PubMed:16380439, ECO:0000269PubMed:16648470, ECO:0000269PubMed:17132086, ECO:0000269PubMed:17724119, ECO:0000269PubMed:18845190, ECO:0000269PubMed:19841137, ECO:0000269PubMed:19843581, ECO:0000269PubMed:19874786, ECO:0000269PubMed:23348741}; Single-pass type II membrane protein {ECO:0000269PubMed:11593002, ECO:0000269PubMed:12036294, ECO:0000269PubMed:16380439, ECO:0000269PubMed:16648470, ECO:0000269PubMed:17132086, ECO:0000269PubMed:17724119, ECO:0000269PubMed:18845190, ECO:0000269PubMed:19841137, ECO:0000269PubMed:19843581, ECO:0000269PubMed:19874786, ECO:0000269PubMed:23348741}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in cochlear outer hair cells (at protein level). {ECO:0000269PubMed:12036294, ECO:0000269PubMed:16380439, ECO:0000269PubMed:17132086, ECO:0000269PubMed:23348741}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005521	lamin binding

Biological Process

GO:0006998	nuclear envelope organization
GO:0090286	cytoskeletal anchoring at nuclear membrane
GO:0090292	nuclear matrix anchoring at nuclear membrane

Cellular Component

GO:0002080	acrosomal membrane
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005639	integral component of nuclear inner membrane
GO:0005737	cytoplasm
GO:0016021	integral component of membrane
GO:0034993	SUN-KASH complex