InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ghr

Summary

InnateDB Protein

IDBP-259715.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ghr

Protein Name

growth hormone receptor

Synonyms

GHBP; GHR/BP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106325

InnateDB Gene

IDBG-127871 (Ghr)

Protein Structure

UniProt Annotation

Function

Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). {ECO:0000250}.The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway. {ECO:0000250}.Isoform 2: Secreted.Growth hormone-binding protein: Secreted {ECO:0000250}. Note=Complexed to a substantial fraction of circulating GH. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in all tissues tested including, liver, heart, adipose tissue, mammary gland, testes, ovary, brain, kidney and muscle. Highest levels in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004903	growth hormone receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0019838	growth factor binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0042169	SH2 domain binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0000255	allantoin metabolic process
GO:0006101	citrate metabolic process
GO:0006103	2-oxoglutarate metabolic process
GO:0006105	succinate metabolic process
GO:0006107	oxaloacetate metabolic process
GO:0006549	isoleucine metabolic process
GO:0006573	valine metabolic process
GO:0006600	creatine metabolic process
GO:0006631	fatty acid metabolic process
GO:0006897	endocytosis
GO:0007259	JAK-STAT cascade
GO:0009755	hormone-mediated signaling pathway
GO:0019221	cytokine-mediated signaling pathway
GO:0019530	taurine metabolic process
GO:0031623	receptor internalization
GO:0032094	response to food
GO:0032355	response to estradiol
GO:0032869	cellular response to insulin stimulus
GO:0040014	regulation of multicellular organism growth
GO:0040018	positive regulation of multicellular organism growth
GO:0042977	activation of JAK2 kinase activity
GO:0043278	response to morphine
GO:0044236	multicellular organismal metabolic process
GO:0045597	positive regulation of cell differentiation
GO:0046449	creatinine metabolic process
GO:0046898	response to cycloheximide
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051384	response to glucocorticoid
GO:0060351	cartilage development involved in endochondral bone morphogenesis
GO:0060396	growth hormone receptor signaling pathway
GO:0070555	response to interleukin-1
GO:1901215	negative regulation of neuron death

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0019898	extrinsic component of membrane
GO:0043025	neuronal cell body
GO:0070195	growth hormone receptor complex