InnateDB Protein
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IDBP-260136.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hmgb1
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Protein Name
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high mobility group box 1
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Synonyms
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amphoterin; DEF; HMG-1; Hmg1; p30; SBP-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000106132
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InnateDB Gene
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IDBG-209311 (Hmgb1)
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Protein Structure
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Function |
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. {ECO:0000269PubMed:9184213}.
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Subcellular Localization |
Nucleus. Cytoplasm. Chromosome. Note=Associated with the plasma membrane of filipodia in process- growing cells, and also deposited into the substrate-attached material.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
Experimentally validated |
Total |
44
[view]
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Protein-Protein |
41
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
62 [view]
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Molecular Function |
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Biological Process |
GO:0002437
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inflammatory response to antigenic stimulus
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GO:0006288
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base-excision repair, DNA ligation
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GO:0006954
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inflammatory response
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GO:0017055
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negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
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GO:0033151
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V(D)J recombination
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GO:0043065
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positive regulation of apoptotic process
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GO:0043280
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positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0043388
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positive regulation of DNA binding
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GO:0045087
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innate immune response (InnateDB)
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:2000426
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negative regulation of apoptotic cell clearance
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Cellular Component |
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PDB ID |
MGI:96113
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InterPro |
IPR009071
High mobility group box domain
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PFAM |
PF00505
PF09011
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PRINTS |
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PIRSF |
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SMART |
SM00398
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TIGRFAMs |
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Modification |
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SwissProt |
P63158
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PhosphoSite |
PhosphoSite-P63158
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TrEMBL |
Q8C7C4
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UniProt Splice Variant |
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Entrez Gene |
619937
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UniGene |
Mm.470617
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RefSeq |
XP_006504870
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MGI ID |
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MGI Symbol |
Hmgb1
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OMIM |
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CCDS |
CCDS19883
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HPRD |
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IMGT |
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EMBL |
AC158782
AK037928
AK050659
AK082902
AK084841
AK157846
BC006586
BC008565
BC083067
BC085090
BC091741
BC094030
BC110667
BC111468
L38477
U00431
X80457
Z11997
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GenPept |
AAA20508
AAA57042
AAH06586
AAH08565
AAH83067
AAH85090
AAH91741
AAH94030
AAI10668
AAI11469
BAC29902
BAC34367
BAC38678
BAC39289
BAE34226
CAA56631
CAA78042
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