Version 5.4
Homo sapiens Protein: EXOG
Summary
InnateDB Protein IDBP-26034.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXOG
Protein Name endo/exonuclease (5'-3'), endonuclease G-like
Synonyms ENDOGL1; ENDOGL2; ENGL; ENGL-a; ENGL-b; ENGLA; ENGLB;
Species Homo sapiens
Ensembl Protein ENSP00000287675
InnateDB Gene IDBG-26030 (EXOG)
Protein Structure
UniProt Annotation
Function Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity. {ECO:0000269PubMed:18187503}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000269PubMed:18187503}.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Protein Structure and Domains
PDB ID
InterPro IPR001604 DNA/RNA non-specific endonuclease
IPR020821 Extracellular Endonuclease, subunit A
PFAM PF01223
PRINTS
PIRSF
SMART SM00892
SM00477
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2C4
PhosphoSite PhosphoSite-Q9Y2C4
TrEMBL
UniProt Splice Variant
Entrez Gene 9941
UniGene Hs.517897
RefSeq NP_005098
HUGO HGNC:3347
OMIM 604051
CCDS CCDS2680
HPRD 06813
IMGT
EMBL AB020523 AB020735 AK289602 AK290107 AK301067 AK315814 BC104212 BC104213 CH471055
GenPept AAI04213 AAI04214 BAA76752 BAA76753 BAF82291 BAF82796 BAF98705 BAG62674 EAW64538

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca