InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOX15

Summary

InnateDB Protein

IDBP-26078.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOX15

Protein Name

SRY (sex determining region Y)-box 15

Synonyms

SOX20; SOX26; SOX27;

Species

Homo sapiens

Ensembl Protein

ENSP00000355354

InnateDB Gene

IDBG-26076 (SOX15)

Protein Structure

UniProt Annotation

Function

Binds to the 5'-AACAAT-3' sequence.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}.

Disease Associations

Tissue Specificity

Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis. {ECO:0000269PubMed:8978787, ECO:0000269PubMed:9880678}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006325	chromatin organization
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008584	male gonad development
GO:0014718	positive regulation of satellite cell activation involved in skeletal muscle regeneration
GO:0030154	cell differentiation
GO:0043403	skeletal muscle tissue regeneration
GO:0045843	negative regulation of striated muscle tissue development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048627	myoblast development
GO:0070318	positive regulation of G0 to G1 transition
GO:2000288	positive regulation of myoblast proliferation