Version 5.4
| Mus musculus Protein: Prokr2 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-260867.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Prokr2 | ||||||
| Protein Name | prokineticin receptor 2 | ||||||
| Synonyms | |||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000105784 | ||||||
| InnateDB Gene | IDBG-207366 (Prokr2) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase (By similarity). {ECO:0000250}. | ||||||
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Expressed in several regions of the brain, including paraventricular hypothalamic nucleus, dorsal medial hypothalamic nucleus, paratenial thalamic nuclei, paracentral thalamic nucleus, lateral habenular nucleus, lateral septal nucleus, lateral globus pallidus and amygdala. Highest expression seen in paraventricular thalamic nuclei and is also extensively expressed in the suprachiasmatic nucleus. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:2181363 | ||||||
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR000611 Neuropeptide Y receptor family IPR017452 GPCR, rhodopsin-like, 7TM IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx |
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| PFAM |
PF00001
PF10320 |
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| PRINTS |
PR00237
PR01012 |
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| PIRSF | |||||||
| SMART | |||||||
| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q8K458 | ||||||
| PhosphoSite | PhosphoSite- | ||||||
| TrEMBL | E0CY28 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 246313 | ||||||
| UniGene | Mm.283777 | ||||||
| RefSeq | |||||||
| MGI ID | |||||||
| MGI Symbol | Prokr2 | ||||||
| OMIM | |||||||
| CCDS | CCDS16773 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AF487279 AK030458 AK041586 AK080980 AL807793 BC043116 | ||||||
| GenPept | AAH43116 AAM49571 BAC26971 BAC30994 BAC38103 CAM21514 | ||||||