Version 5.4
Mus musculus Protein: Macrod2
Summary
InnateDB Protein IDBP-261059.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Macrod2
Protein Name MACRO domain containing 2
Synonyms 1110033L15Rik; 2610107G07Rik; 2900006F19Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000105691
InnateDB Gene IDBG-208164 (Macrod2)
Protein Structure
UniProt Annotation
Function Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the kidney. {ECO:0000269PubMed:17586838}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0019213 deacetylase activity
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0007420 brain development
GO:0042278 purine nucleoside metabolic process
GO:0051725 protein de-ADP-ribosylation
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1920149
InterPro IPR002589 Macro domain
PFAM PF01661
PRINTS
PIRSF
SMART SM00506
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UYG8
PhosphoSite PhosphoSite-Q3UYG8
TrEMBL
UniProt Splice Variant
Entrez Gene 72899
UniGene Mm.382697
RefSeq XP_006500309
MGI ID
MGI Symbol Macrod2
OMIM
CCDS CCDS50733
HPRD
IMGT
EMBL AK134694 AL731795 AL837516 AL844562 AL844582 AL845530 AL928823 AL929027 AL929443
GenPept BAE22244 CAM14291 CAM17747 CAM18117 CAM18237 CAM18246 CAM19545 CAM25240 CAM25366

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca