InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gck

Summary

InnateDB Protein

IDBP-261567.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gck

Protein Name

glucokinase

Synonyms

Gk; GLK; Gls006; HK4; HKIV; HXKP; MODY2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105447

InnateDB Gene

IDBG-145703 (Gck)

Protein Structure

UniProt Annotation

Function

Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Pancreas, anterior pituitary (isoform 1) and liver (isoform 2).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004340	glucokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005536	glucose binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019903	protein phosphatase binding
GO:0043531	ADP binding

Biological Process

GO:0001678	cellular glucose homeostasis
GO:0005975	carbohydrate metabolic process
GO:0005978	glycogen biosynthetic process
GO:0006003	fructose 2,6-bisphosphate metabolic process
GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0006739	NADP metabolic process
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0019932	second-messenger-mediated signaling
GO:0031018	endocrine pancreas development
GO:0032024	positive regulation of insulin secretion
GO:0032811	negative regulation of epinephrine secretion
GO:0032869	cellular response to insulin stimulus
GO:0042149	cellular response to glucose starvation
GO:0042327	positive regulation of phosphorylation
GO:0042593	glucose homeostasis
GO:0043266	regulation of potassium ion transport
GO:0044320	cellular response to leptin stimulus
GO:0045721	negative regulation of gluconeogenesis
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045821	positive regulation of glycolytic process
GO:0046835	carbohydrate phosphorylation
GO:0050796	regulation of insulin secretion
GO:0051156	glucose 6-phosphate metabolic process
GO:0051594	detection of glucose
GO:0070509	calcium ion import