InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COL5A3

Summary

InnateDB Protein

IDBP-26169.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL5A3

Protein Name

collagen, type V, alpha 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000264828

InnateDB Gene

IDBG-26167 (COL5A3)

Protein Structure

UniProt Annotation

Function

Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000255PROSITE-ProRule:PRU00793}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005518	collagen binding
GO:0008201	heparin binding
GO:0043394	proteoglycan binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007411	axon guidance
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030574	collagen catabolic process
GO:0043588	skin development

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0005588	collagen type V
GO:0005788	endoplasmic reticulum lumen
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000885 Fibrillar collagen, C-terminal
IPR001791 Laminin G domain
IPR008160 Collagen triple helix repeat
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF01410
PF00054
PF02210
PF01391

PRINTS

PIRSF

SMART

SM00038
SM00210
SM00282

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P25940