InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MEX3B

Summary

InnateDB Protein

IDBP-26172.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MEX3B

Protein Name

mex-3 homolog B (C. elegans)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000329918

InnateDB Gene

IDBG-26170 (MEX3B)

Protein Structure

UniProt Annotation

Function

RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18779327}. Cytoplasm {ECO:0000269PubMed:18779327}. Cytoplasm, P-body {ECO:0000269PubMed:18779327}. Cytoplasmic granule {ECO:0000269PubMed:18779327}. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.

Disease Associations

Tissue Specificity

Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level. {ECO:0000269PubMed:17267406}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding