InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Oprl1

Summary

InnateDB Protein

IDBP-263831.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Oprl1

Protein Name

opioid receptor-like 1

Synonyms

KOR-3; KOR3; LC132; MOR-C; morc; Oprl; ORGC; ORL1; XOR1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104398

InnateDB Gene

IDBG-214226 (Oprl1)

Protein Structure

UniProt Annotation

Function

G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269PubMed:12217419, ECO:0000269PubMed:12814369, ECO:0000269PubMed:23652222, ECO:0000269PubMed:7603458, ECO:0000269PubMed:8794880}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle {ECO:0000250}. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-360. Can recycle to the cell membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

In the brain, isoform KOR3 and isoform KOR3C are most abundant in hypothalamus and periaqueductal gray. Isoform KOR3A is highly expressed in cortex, striatum and brainstem. Isoform KOR3D is highly expressed in cerebellum, hypothalamus and brainstem. Detected in spleen lymphocytes. {ECO:0000269PubMed:7603458, ECO:0000269PubMed:7797625, ECO:0000269PubMed:9755860}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001626	nociceptin receptor activity
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007610	behavior
GO:0019233	sensory perception of pain
GO:0038003	opioid receptor signaling pathway

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle

Protein Structure and Domains

PDB ID

MGI:97440

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000586 Somatostatin receptor family
IPR000611 Neuropeptide Y receptor family
IPR001418 Opioid receptor
IPR001420 X opioid receptor
IPR009150 Neuropeptide B/W receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10323
PF10328

PRINTS

PR00237
PR00246
PR01012
PR00384
PR00547
PR01855

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35377