InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pard3

Summary

InnateDB Protein

IDBP-263864.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pard3

Protein Name

par-3 (partitioning defective 3) homolog (C. elegans)

Synonyms

AA960621; AI256638; ASIP; D8Ertd580e; PAR-3; Par3; Pard3a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104383

InnateDB Gene

IDBG-200951 (Pard3)

Protein Structure

UniProt Annotation

Function

Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination. {ECO:0000250, ECO:0000269PubMed:21949390}.

Subcellular Localization

Cytoplasm. Endomembrane system. Cell junction. Cell junction, tight junction. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane {ECO:0000250}. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (By similarity). Colocalized with SIRT2 in internode region of myelin sheat. {ECO:0000250}.

Disease Associations

Tissue Specificity

All isoforms are expressed in heart, while expression in brain is mainly limited to isoform 1, and to isoform 3 to a weaker level.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0032266	phosphatidylinositol-3-phosphate binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0003383	apical constriction
GO:0006612	protein targeting to membrane
GO:0007049	cell cycle
GO:0007163	establishment or maintenance of cell polarity
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0016337	single organismal cell-cell adhesion
GO:0022011	myelination in peripheral nervous system
GO:0031643	positive regulation of myelination
GO:0032970	regulation of actin filament-based process
GO:0044319	wound healing, spreading of cells
GO:0051301	cell division
GO:0051642	centrosome localization
GO:0070830	tight junction assembly
GO:0090162	establishment of epithelial cell polarity

Cellular Component

GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005923	tight junction
GO:0005938	cell cortex
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0030054	cell junction
GO:0033269	internode region of axon
GO:0043219	lateral loop
GO:0043220	Schmidt-Lanterman incisure
GO:0043234	protein complex
GO:0045177	apical part of cell