InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dlg4

Summary

InnateDB Protein

IDBP-264213.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dlg4

Protein Name

discs, large homolog 4 (Drosophila)

Synonyms

Dlgh4; PSD-95; PSD95; SAP90; SAP90A;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104230

InnateDB Gene

IDBG-193317 (Dlg4)

Protein Structure

UniProt Annotation

Function

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. {ECO:0000269PubMed:15358775, ECO:0000269PubMed:9853749}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000269PubMed:24153177}. Note=Membrane-associated. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 372 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.

Experimentally validated
Total	372 [view]
Protein-Protein	372 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	84 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019903	protein phosphatase binding
GO:0030165	PDZ domain binding
GO:0031697	beta-1 adrenergic receptor binding
GO:0031748	D1 dopamine receptor binding
GO:0031812	P2Y1 nucleotide receptor binding
GO:0032403	protein complex binding
GO:0033130	acetylcholine receptor binding
GO:0035255	ionotropic glutamate receptor binding
GO:0042043	neurexin family protein binding
GO:0097110	scaffold protein binding

Biological Process

GO:0002091	negative regulation of receptor internalization
GO:0006461	protein complex assembly
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007626	locomotory behavior
GO:0016188	synaptic vesicle maturation
GO:0035176	social behavior
GO:0035418	protein localization to synapse
GO:0035641	locomotory exploration behavior
GO:0042220	response to cocaine
GO:0045184	establishment of protein localization
GO:0048168	regulation of neuronal synaptic plasticity
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0050806	positive regulation of synaptic transmission
GO:0050885	neuromuscular process controlling balance
GO:0060997	dendritic spine morphogenesis
GO:0071625	vocalization behavior
GO:0097113	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0097120	receptor localization to synapse
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential
GO:2000821	regulation of grooming behavior

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0008328	ionotropic glutamate receptor complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0030863	cortical cytoskeleton
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0032839	dendrite cytoplasm
GO:0043197	dendritic spine
GO:0044224	juxtaparanode region of axon
GO:0044300	cerebellar mossy fiber
GO:0044306	neuron projection terminus
GO:0044309	neuron spine
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse
GO:0097481	neuronal postsynaptic density

Protein Structure and Domains

PDB ID

MGI:1277959

InterPro

IPR001452 SH3 domain
IPR001478 PDZ domain
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR015143 L27-1
IPR016313 Disks large 1
IPR019583 PDZ-associated domain of NMDA receptors
IPR019590 Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM